Over 10% of the U.S is affected by poorly functioning valves in the veins of legs and advanced vein disease. These poorly functioning valves allow blood to flow backward and pool in the legs. This pooling causes vein dilation, pain, a poor wound-healing environment, and recurring leg wounds, for which there is no definitive cure. 

 

 Recurring leg wounds affect millions in the United States alone.

Management costs ~$10,000+ per active wound per year, and in aggregate, billions to the U.S. healthcare system annually.

Current treatment is palliative, leaving up to half this population with recurrent wounds for years to decades.

Others often remain with advanced symptoms including pain, leg swelling, and skin thickening.

 Still, there is no option for prosthetic valve replacement on the market.